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KMID : 0370220160600040193
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Yakhak Hoeji
2016 Volume.60 No. 4 p.193 ~ p.199
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Prolonged Enhancement in Locomotor Activity in Aged Rats by Positive Autoregulatory Expression of Glial Cell Derived Neurotrophic Factor
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Nikita Katila
Choi Dong -Young
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Abstract
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We evaluated the effects of single infusion of glial cell derived neurotrophic factor (GDNF) on locomotor activity in aged rats. Enhanced activity for four weeks was accompanied by an increase in sizes of the nigral dopaminergic neurons, areas of their nuclei and cytoplasm. We found that increased level of neurotrophic factors sustained in the striatum up to four weeks. There was significant rise in the level of GDNF mRNA in the striatum following GDNF treatment. These results suggest that exogenous GDNF infusion stimulates expression of itself in the brain which is related to prolonged effects of the neurotrophic factor.
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KEYWORD
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glial cell derived neurotrophic factor, autoregulation, locomotor activity, aging
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